Combatting Salmonella: a focus on antimicrobial resistance and the need for effective vaccination

Salmonella infections are a major global public health concern due to their zoonotic transmission, antimicrobial resistance, and associated morbidity and mortality. A systematic review of literature found that they result in 95 million global cases annually, with 150,000 deaths. Regional variations are evident, with higher infection rates in low- and middle-income countries. The most prevalent serovars are Salmonella Enteritidis and S. Typhimurium. Despite progress in vaccine development, challenges remain in achieving a universal vaccine targeting diverse serovars. A multifaceted approach is needed, including improved sanitation, prudent antibiotic use, and affordable, broad-spectrum vaccines.